
Rising Costs Offset Strong Revenue at Mayo Clinic in Q2 2025
Rochester, MN (KROC-AM News) - Despite a big jump from investment returns, Mayo Clinic experienced a modest decline in net income during the second quarter of this year.
A required financial filing shows Mayo Clinic’s income from current activities—considered a key measure of its financial performance—was reported at $394 million for the three-month period that ended in June. That’s down about $54 million, or roughly 12%, compared with the second quarter of last year. It was up about 9.7% compared with the first quarter of this year.
Mayo Clinic reported more than $5.34 billion in revenues from April through June, including more than $4.5 billion in medical service revenue. Compared with the second quarter of last year, total revenue was up $337 million, or 6.7%.

At the same time, Mayo Clinic’s expenses grew faster. The total for the second quarter was about $4.95 billion—about $391 million, or 8.5%, higher than the same three-month period a year ago. The report shows Mayo’s spending on salaries and benefits increased about 7.5% year-over-year.
SEE ALSO: Mayo Clinic Starts 2025 Strong with $359M in Q1 Income
The filing indicates the healthcare giant’s returns from investments jumped from $49 million last year to $580 million in the second quarter of this year.
For the first six months of 2025, Mayo Clinic’s revenues rose 7.3% compared with the first half of 2024, totaling about $10.4 billion. Expenses for the first half of the year climbed 8.3% to about $9.68 billion.
Income from current activities was down about $36 million from the first half of last year, at about $753 million.
All of the monetary figures listed in the story are based on Mayo Clinic reported revenues, expenses, and income from current activities without donor restrictions.
The unaudited report was filed with the online Electronic Municipal Market Access site, a service of the Municipal Securities Rulemaking Board. The report is required because of municipal bonds sold by Mayo to finance various economic development projects.
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